Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand

Khan, Raysa, Marsh, Graham, Felix, Robert, Kemmitt, Paul D, Baud, Matthias G J, Ciulli, Alessio and Spencer, John (2017) Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand. ACS Omega, 2 (8). pp. 4328-4332. ISSN 2470-1343

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Abstract

TC AC 28, 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester, has been synthesized on a near gram scale in seven steps with notable improvements in the reported poor yielding last 2 steps enabling this key chemical probe compound to be available for researchers.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User: John Spencer
Date Deposited: 28 Jul 2017 08:55
Last Modified: 02 Oct 2017 09:25
URI: http://sro.sussex.ac.uk/id/eprint/69509

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A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs iCASEG1436EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCILEP/M507568/1