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Cardiovascular mitochondrial dysfunction induced by cocaine: biomarkers and possible beneficial effects of modulators of oxidative stress
journal contribution
posted on 2023-06-09, 07:17 authored by Manuela Graziani, Paolo Sarti, Marzia Arese, Maria Chiara Magnifico, Aldo Badiani, Luciano SasoCocaine abuse has long been known to cause morbidity and mortality due to its cardiovascular toxic effects. The pathogenesis of the cardiovascular toxicity of cocaine use has been largely reviewed, and the most recent data indicate a fundamental role of oxidative stress in cocaine-induced cardiovascular toxicity, indicating that mitochondrial dysfunction is involved in the mechanisms of oxidative stress. The comprehension of the mechanisms involving mitochondrial dysfunction could help in selecting the most appropriate mitochondria injury biological marker, such as superoxide dismutase-2 activity and glutathionylated hemoglobin. The potential use of modulators of oxidative stress (mitoubiquinone, the short-chain quinone idebenone, and allopurinol) in the treatment of cocaine cardiotoxic effects is also suggested to promote further investigations on these potential mitochondria-targeted antioxidant strategies.
History
Publication status
- Published
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- Published version
Journal
Oxidative Medicine and Cellular LongevityISSN
1942-0900Publisher
HindawiExternal DOI
Volume
2017Article number
a3034245Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-07-20First Open Access (FOA) Date
2017-07-20First Compliant Deposit (FCD) Date
2017-07-20Usage metrics
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