Cardiovascular mitochondrial dysfunction induced by cocaine: biomarkers and possible beneficial effects of modulators of oxidative stress

Graziani, Manuela, Sarti, Paolo, Arese, Marzia, Magnifico, Maria Chiara, Badiani, Aldo and Saso, Luciano (2017) Cardiovascular mitochondrial dysfunction induced by cocaine: biomarkers and possible beneficial effects of modulators of oxidative stress. Oxidative Medicine and Cellular Longevity, 2017. a3034245. ISSN 1942-0900

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Abstract

Cocaine abuse has long been known to cause morbidity and mortality due to its cardiovascular toxic effects. The pathogenesis of the cardiovascular toxicity of cocaine use has been largely reviewed, and the most recent data indicate a fundamental role of oxidative stress in cocaine-induced cardiovascular toxicity, indicating that mitochondrial dysfunction is involved in the mechanisms of oxidative stress. The comprehension of the mechanisms involving mitochondrial dysfunction could help in selecting the most appropriate mitochondria injury biological marker, such as superoxide dismutase-2 activity and glutathionylated hemoglobin. The potential use of modulators of oxidative stress (mitoubiquinone, the short-chain quinone idebenone, and allopurinol) in the treatment of cocaine cardiotoxic effects is also suggested to promote further investigations on these potential mitochondria-targeted antioxidant strategies.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Depositing User: Ellena Adams
Date Deposited: 20 Jul 2017 08:54
Last Modified: 20 Jul 2017 09:00
URI: http://sro.sussex.ac.uk/id/eprint/69341

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