Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders

Boldrini, Paolo, Fusco, Antonella, Nicoletti, Ferdinando, Badiani, Aldo and Saso, Luciano (2017) Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders. Current Drug Targets. ISSN 1389-4501 (Accepted)

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Abstract

It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. In this review we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.

Item Type: Article
Keywords: Oxidative stress modulators, anxiety disorders, anxiety models, reactive oxygen species, reactive nitrogen species, lipid peroxidation
Schools and Departments: School of Psychology > Psychology
Depositing User: Ellena Adams
Date Deposited: 19 Jul 2017 14:53
Last Modified: 19 Jul 2017 15:01
URI: http://sro.sussex.ac.uk/id/eprint/69333

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