Childhood poverty is associated with altered hippocampal function and visuospatial memory in adulthood

Duval, Elizabeth R, Garfinkel, Sarah N, Swain, James E, Evans, Gary W, Blackburn, Erika K, Angstadt, Mike, Sripada, Chandra S and Liberzon, Israel (2017) Childhood poverty is associated with altered hippocampal function and visuospatial memory in adulthood. Developmental Cognitive Neuroscience, 23. pp. 39-44. ISSN 1878-9293

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Abstract

Childhood poverty is a risk factor for poorer cognitive performance during childhood and adulthood. While evidence linking childhood poverty and memory deficits in adulthood has been accumulating, underlying neural mechanisms are unknown. To investigate neurobiological links between childhood poverty and adult memory performance, we used functional magnetic resonance imaging (fMRI) during a visuospatial memory task in healthy young adults with varying income levels during childhood. Participants were assessed at age 9 and followed through young adulthood to assess income and related factors. During adulthood, participants completed a visuospatial memory task while undergoing MRI scanning. Patterns of neural activation, as well as memory recognition for items, were assessed to examine links between brain function and memory performance as it relates to childhood income. Our findings revealed associations between item recognition, childhood income level, and hippocampal activation. Specifically, the association between hippocampal activation and recognition accuracy varied as a function of childhood poverty, with positive associations at higher income levels, and negative associations at lower income levels. These prospective findings confirm previous retrospective results detailing deleterious effects of childhood poverty on adult memory performance. In addition, for the first time, we identify novel neurophysiological correlates of these deficits localized to hippocampus activation.

Item Type: Article
Keywords: Visuospatial memory; Hippocampus; fMRI; Childhood poverty
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
Depositing User: Alexei Fisk
Date Deposited: 16 Jun 2017 14:31
Last Modified: 26 Jul 2017 15:46
URI: http://sro.sussex.ac.uk/id/eprint/68664

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