Comprehensive geriatric assessment in men aged 70 years or older with localised prostate cancer undergoing radical radiotherapy

Osborne, G E C, Appleyard, S A, Gilbert, D C, Jones, C I, Villanueva, M, Peasgood, E, Robinson, A, Nikapota, A and Ring, A (2017) Comprehensive geriatric assessment in men aged 70 years or older with localised prostate cancer undergoing radical radiotherapy. Clinical Oncology, 29 (9). pp. 609-616. ISSN 0936-6555

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Abstract

Aims
Treatment decisions for men aged 70 years or over with localised prostate cancer need to take into account the risk of death from competing causes and fitness for the proposed treatment. Objective assessments such as those included in a comprehensive geriatric assessment (CGA) might help to inform the decision-making process. The aim of this study was to describe the CGA scores of a cohort of older men with prostate cancer, evaluate potential screening tools in this population and assess whether any CGA component predicts significant acute radiotherapy toxicity.
Materials and methods
This was a prospective cohort study undertaking pretreatment CGA, Vulnerable Elders Survey (VES-13) and G8 assessment in patients aged 70 years and over with localised prostate cancer planned to undergo radical external beam radiotherapy.
Results
In total, 178 participants were recruited over a 3 year period and underwent a CGA. Fifty-five (30.1%) participants were defined as having health needs identified by their CGA. Both VES-13 and G8 screening tools showed a statistically significant association with CGA needs (P < 0.001 and X2 = 15.02, P < 0.001, respectively), but their sensitivity was disappointing. There was no association between a CGA (or its components) and significant acute radiotherapy toxicity.
Conclusions
Many older men with localised prostate cancer are vulnerable according to a CGA. The screening tools evaluated were not sufficiently sensitive to identify this group. CGA outcome does not predict for significant acute radiotherapy toxicity.

Item Type: Article
Keywords: Comprehensive geriatric assessment; elderly; geriatric oncology; prostate cancer; radiotherapy tolerance; screening tests; toxicity
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Subjects: R Medicine
Depositing User: Chris Jones
Date Deposited: 20 Jun 2017 14:16
Last Modified: 03 Sep 2017 22:32
URI: http://sro.sussex.ac.uk/id/eprint/68275

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Project NameSussex Project NumberFunderFunder Ref
Prostate Cancer in Older Men Over Seventy (POCAMOS)G0975SUSSEX CANCER FUND FOR TREATMENT AND RESEARCHUnset