Fallowfield, L. J., Atkins, L. A., Catt, S. L., Cox, A., Coxon, C., Langridge, C. I., Morris, R. and Price, M. (2006) Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer. Annals of Oncology, 17 (2). pp. 205-210. ISSN 0923-7534Full text not available from this repository.
BACKGROUND: Endocrine therapies for advanced breast cancer include tablets and intramuscular injections. When treatments have similar efficacy and tolerability profiles, addressing preferences about routes of administration is important. PATIENTS AND METHODS: Two hundred and eight women>2 years post-breast cancer diagnosis were interviewed about their preferences for daily tablets or monthly intramuscular injections. Health-care professionals treating the women estimated patients' preferences. RESULTS: Sixty-three per cent of patients preferred tablets, 24.5% preferred the injection and 12.5% had no preference. The most cited reasons for tablet preference were convenience and dislike of needles; for injection preference, adherence and convenience. Variables associated with preferences were body mass index, educational level, attitudes towards injections and efficacy perceptions. Estimates about patients' preferences by health-care professionals varied widely. When asked to imagine scenarios where injections produced fewer hot flushes, or where two injections monthly improved efficacy, injection preference increased to 60.6% and 74.5%, respectively. Disturbingly, approximately 50% of patients admitted they sometimes forgot or chose not to take their current oral medication. CONCLUSIONS: The majority of breast cancer patients preferred hormone therapy via daily tablets rather than monthly injections. Information about side-effects or improved efficacy altered these preferences. Adherence to treatment cannot be assumed; patients' preferences about drug administration may influence this.
|Schools and Departments:||Brighton and Sussex Medical School > Brighton and Sussex Medical School|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens|
|Depositing User:||Tracy Woodcock|
|Date Deposited:||15 Dec 2006|
|Last Modified:||08 Jun 2012 08:31|
|Google Scholar:||58 Citations|