The effect of spacer morphology on the aerosolization performance of metered-dose inhalers

Momeni, Sepideh, Nokhodchi, Ali, Ghanbarzadeh, Saeed and Hamishehkar, Hamed (2016) The effect of spacer morphology on the aerosolization performance of metered-dose inhalers. Advanced Pharmaceutical Bulletin, 6 (2). pp. 257-260. ISSN 2228-5881

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Abstract

Purpose: Respiratory drug delivery has been attracted great interest for the past decades, because of the high incidence of pulmonary diseases. However, despite its invaluable benefits, there are some major drawbacks in respiratory drug delivery, mainly due to the relatively high drug deposition in undesirable regions. One way to improve the efficiency of respiratory drug delivery through metered-dose inhalers (MDI) is placing a respiratory spacer between the inhaler exit and the mouth. The aim of this study was to assess the effect of type and shape of spacer on the aerosolization performance of MDIs.

Methods: A commercial Beclomethasone Dipropionate (BDP) MDI alone or equipped with two different spacer devices (roller and pear type) widely distributed in the world pharmaceutical market was used. The effect of spacers was evaluated by calculating aerosolization indexes such as fine particle fraction (FPF), mass median aerodynamic diameters (MMAD) and geometric standard deviation (GSD) using the next generation impactor.

Results: Although one of the spacers resulted in superior outcomes than the other one, but it was not statistically significant.

Conclusion: The results confirmed that the type and shape of spacer did not substantially influence the aerosolization performance of MDIs.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0192 Pharmaceutical technology
Depositing User: Ali Nokhodchi
Date Deposited: 08 May 2017 15:34
Last Modified: 08 May 2017 15:41
URI: http://sro.sussex.ac.uk/id/eprint/67755

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