University of Sussex
Browse
APB-spacer.pdf (277.94 kB)

The effect of spacer morphology on the aerosolization performance of metered-dose inhalers

Download (277.94 kB)
journal contribution
posted on 2023-06-09, 06:12 authored by Sepideh Momeni, Ali Nokhodchi, Saeed Ghanbarzadeh, Hamed Hamishehkar
Purpose: Respiratory drug delivery has been attracted great interest for the past decades, because of the high incidence of pulmonary diseases. However, despite its invaluable benefits, there are some major drawbacks in respiratory drug delivery, mainly due to the relatively high drug deposition in undesirable regions. One way to improve the efficiency of respiratory drug delivery through metered-dose inhalers (MDI) is placing a respiratory spacer between the inhaler exit and the mouth. The aim of this study was to assess the effect of type and shape of spacer on the aerosolization performance of MDIs. Methods: A commercial Beclomethasone Dipropionate (BDP) MDI alone or equipped with two different spacer devices (roller and pear type) widely distributed in the world pharmaceutical market was used. The effect of spacers was evaluated by calculating aerosolization indexes such as fine particle fraction (FPF), mass median aerodynamic diameters (MMAD) and geometric standard deviation (GSD) using the next generation impactor. Results: Although one of the spacers resulted in superior outcomes than the other one, but it was not statistically significant. Conclusion: The results confirmed that the type and shape of spacer did not substantially influence the aerosolization performance of MDIs.

History

Publication status

  • Published

File Version

  • Published version

Journal

Advanced Pharmaceutical Bulletin

ISSN

2228-5881

Publisher

Tabriz University of Medical Sciences

Issue

2

Volume

6

Page range

257-260

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-05-08

First Open Access (FOA) Date

2017-05-08

First Compliant Deposit (FCD) Date

2017-05-08

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC