An in vitro aerosolization efficiency comparison of generic and branded salbutamol metered dose inhalers

Rahimkhani, Sara, Ghanbarzadeh, Saeed, Nokhodchi, Ali and Hamishehkar, Hamed (2017) An in vitro aerosolization efficiency comparison of generic and branded salbutamol metered dose inhalers. Pharmaceutical Sciences, 23 (1). pp. 77-81. ISSN 1735-403X

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Abstract

Background: Due to the high rate of pulmonary diseases, respiratory drug delivery systems have been attracted excessive attention for the past decades. Because of limitations and growing drug bill, physicians are encouraged to prescribe generically whenever possible. The purpose of this study was to evaluate whether there was any significant difference in aerosolization performance between a reference brand Salbutamol (A) Metered Dose Inhalers (MDIs) and two generic products (B and C).

Methods: The aerosolization performance of MDIs was evaluated by calculating aerosolization indexes including fine particle fraction (FPF), fine particle dose (FPD), geometric standard deviation (GSD) and mass median
aerodynamic diameters (MMAD) by using the next generation impactor.

Results: Although aerosolization indexes of MDI A were superior than the Iranian brands, but the differences were not statistically significant.

Conclusion: These results verified that generic MDIs deliver similar quantities of Salbutamol to the reference brand and aerosolization performance parameters of generic Salbutamol MDIs did not differ significantly from the reference brand.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0192 Pharmaceutical technology
Depositing User: Ali Nokhodchi
Date Deposited: 08 May 2017 14:19
Last Modified: 08 May 2017 14:28
URI: http://sro.sussex.ac.uk/id/eprint/67739

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