Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

McLaughlin, Russell L, Leigh, P Nigel, Project MinE, GWAS Consortium and Schizophrenia Working Group of the Psychiatric, Genomics Consortium (2017) Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications, 8. a14774. ISSN 2041-1723

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Abstract

We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05–21.6; P=1 × 10−4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10−7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08–1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

Item Type: Article
Keywords: Amyotrophic Lateral Sclerosis Genetics Research Motor Neuron Disease Schizophrenia
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 03 May 2017 13:24
Last Modified: 28 Jul 2017 20:50
URI: http://sro.sussex.ac.uk/id/eprint/67642

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