Relationship between serum anti-heat shock protein 27 antibody levels and obesity

Kargar, Mehrdad, Tavassoli, Samira, Avan, Amir, Ebrahim, Mahmoud, Azarpazhooh, Mahmoud Reza, Asoodeh, Rasool, Nematy, Mohsen, Hassanian, Seyed Mahdi, Rahmani, Farzad, Mohammadzade, Elham, Esmaeili, Habibollah, Moohebat, Mohsen, Ferns, Gordon A, Ghayour-Mobarhan, Majid and Parizadeh, Seyed Mohammed Reza (2017) Relationship between serum anti-heat shock protein 27 antibody levels and obesity. Clinical Biochemistry. ISSN 0009-9120

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Abstract

Background: Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is
expressed at high levels following the exposure of cells to environmental stressors such as
heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been
reported in several conditions including cardiovascular disease and cancers. We measured
serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between
serum anti-HSP27 antibody levels and demographic characteristics including coronary risk
factors.
Methods: A total of 993 subjects were recruited as part of the Mashhad Stroke and Heart
Atherosclerotic Disorders (MASHAD) cohort study. Demographic, clinical, and biochemical
parameters and serum anti-HSP27 antibody titers were determined in all the subjects.
Results: Serum anti-HSP27 antibody levels increased with increasing age in men. No
significant differences in levels were detected between men and women. Serum anti-HSP27
antibody levels were significantly higher in obese subjects than in nonobese subjects
(P=0.046); however, no significant influence of smoking status was observed. Moreover,
serum anti-HSP27 antibody titers were positively associated with age, body mass index,
waist/hip ratio, the presence of diabetes mellitus, nonsmoking habit, serum triglycerides,
cholesterol, and high-sensitivity c-reactive protein.
Conclusion: We have found that serum anti-HSP27 antibody titers are related to several
cardiovascular risk factors, necessitating further studies on the value of this emerging marker
for risk stratification.

Item Type: Article
Keywords: Anti-heat Shock Protein 27, Cardiovascular Risk Factors, Determinants
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 24 Apr 2017 08:46
Last Modified: 24 Apr 2017 08:52
URI: http://sro.sussex.ac.uk/id/eprint/67463

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