High dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow up study

Khayyatzadeh, Sayyed Saeid, Mirmousavi, Seyed Jamal, Fazeli, Mostafa, Abasalti, Zahra, Avan, Amir, Javandoost, Ali, Rahmani, Farzad, Tayefi, Maryam, Hanachi, Parichehr, Ferns, Gordon A, Bahrami Taghanaki, Hamidreza and Ghayour-Mobarhan, Majid (2017) High dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow up study. Annals of Clinical Biochemistry. ISSN 0004-5632

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Abstract

Background: Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here we explored the effects of high-dose vitamin D supplementation on cardiometabolic risk factors.
Methods: We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurements were obtained at baseline and after supplementation with high dose vitamin D. All individuals took a capsule of 50000 IU vitamin D/ week for nine weeks. The study was completed by 940 participants.
Results: the prevalence of vitamin D deficiency was 90% at baseline, reducing to16.3% after vitamin D supplementation. Vitamin supplementation was associated with a significant increase in serum levels of 25 (OH) vitamin D and calcium. There were significant reductions in diastolic blood pressure, heart rate, waist circumference, and serum fasting blood glucose, total- and low density lipoprotein-cholesterol after the nine-week period on vitamin D treatment, but no significant effects were observed on body mass index, systolic blood pressure, or serum high density lipoprotein-cholesterol and triglyceride.
Conclusion: vitamin D supplementation had beneficial effects on cardio-metabolic profile in adolescent girls.

Item Type: Article
Keywords: Vitamin D, cardiometabolic, supplementation, adolescent
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 24 Apr 2017 08:15
Last Modified: 25 Aug 2017 16:26
URI: http://sro.sussex.ac.uk/id/eprint/67460

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