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Repair of DNA double-strand breaks in heterochromatin

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posted on 2023-06-09, 05:25 authored by Felicity Watts
DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the complexity of the break or the position of the break within the chromatin. In eukaryotic cells, nuclear DNA is maintained as either euchromatin (EC) which is loosely packed, or in a denser form, much of which is heterochromatin (HC). Due to the less accessible nature of the DNA in HC as compared to that in EC, repair of damage in HC is not as straightforward as repair in EC. Here we review the literature on how cells deal with DSBs in HC.

History

Publication status

  • Published

File Version

  • Published version

Journal

Biomolecules

ISSN

2218-273X

Publisher

MDPI

Issue

4

Volume

6

Page range

47

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-04-19

First Open Access (FOA) Date

2017-04-19

First Compliant Deposit (FCD) Date

2017-04-19

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