Current source enhancements in Electrical Impedance Spectroscopy (EIS) to cancel unwanted capacitive effects

Zarafshani, Ali, Bach, Thomas, Chatwin, Chris, Xiang, Liangzhong and Zheng, Bin (2017) Current source enhancements in Electrical Impedance Spectroscopy (EIS) to cancel unwanted capacitive effects. Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, Florida, United States, February 11-16, 2017. Published in: Proceedings of SPIE, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging. 10137 101371X. SPIE, SPIE USA. ISSN 1605-7422

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Abstract

Electrical Impedance Spectroscopy (EIS) has emerged as a non-invasive imaging modality to detect and quantify functional or electrical properties related to the suspicious tumors in cancer screening, diagnosis and prognosis assessment. A constraint on EIS systems is that the current excitation system suffers from the effects of stray capacitance having a major impact on the hardware subsystem as the EIS is an ill-posed inverse problem which depends on the noise level in EIS measured data and regularization parameter in the reconstruction algorithm. There is high complexity in the design of stable current sources, with stray capacitance reducing the output impedance and bandwidth of the system. To confront this, we have designed an EIS current source which eliminates the effect of stray capacitance and other impacts of the capacitance via a variable inductance. In this paper, we present a combination of operational CCII based on a generalized impedance converter (OCCII-GIC) with a current source. The aim of this study is to use the EIS system as a biomedical imaging technique, which is effective in the early detection of breast cancer. This article begins with the theoretical description of the EIS structure, current source topologies and proposes a current conveyor in application of a Gyrator to eliminate the current source limitations and its development followed by simulation and experimental results. We demonstrated that the new design could achieve a high output impedance over a 3MHz frequency bandwidth when compared to other types of GIC circuits combined with an improved Howland topology.

Item Type: Conference Proceedings
Additional Information: Copyright SPIE Proceedings (2017) Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Keywords: Dielectric spectroscopy ; Capacitance ; Computer hardware ; Breast cancer ; Cancer ; Inductance ; Inverse problems ; Medical diagnostics ; Medical imaging modalities ; Reconstruction algorithms
Schools and Departments: School of Engineering and Informatics > Engineering and Design
Research Centres and Groups: Industrial Informatics and Signal Processing Research Group
Subjects: Q Science > QA Mathematics > QA0299 Analysis. Including analytical methods connected with physical problems
R Medicine > R Medicine (General) > R856 Biomedical engineering. Electronics. Instrumentation
R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK0452 Electric apparatus and materials. Electric circuits. Electric networks
T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800 Electronics
Depositing User: Chris Chatwin
Date Deposited: 12 Apr 2017 11:31
Last Modified: 19 Apr 2017 10:13
URI: http://sro.sussex.ac.uk/id/eprint/67392

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