__smbhome.uscs.susx.ac.uk_hw49_Documents_files from 11 Oct 2016_my papers_cAMP.pdf (257.99 kB)
cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory
journal contribution
posted on 2023-06-09, 05:39 authored by E Clea Warburton, Colin P J Glover, Peter V Massey, Huimin Wan, Ben Johnson, Alison Bienemann, Ule Deuschle, James N C Kew, John P Aggleton, Zafar I Bashir, James Uney, Malcolm W BrownWe established the importance of phosphorylation of cAMP responsive element-binding protein (CREB) to both the familiarity discrimination component of long-term recognition memory and plasticity within the perirhinal cortex of the temporal lobe. Adenoviral transduction of perirhinal cortex (and adjacent visual association cortex) with a dominant-negative inhibitor of CREB impaired the preferential exploration of novel over familiar objects at a long (24 h) but not a short (15 min) delay, disrupted the normal reduced activation of perirhinal neurons to familiar compared with novel pictures, and impaired long-term potentiation of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for involvement of CREB phosphorylation in synaptic plastic processes within perirhinal cortex necessary for long-term recognition memory.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of NeuroscienceISSN
0270-6474Publisher
Society for NeuroscienceExternal DOI
Issue
27Volume
25Page range
6296-6303Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-04-07First Open Access (FOA) Date
2017-04-07First Compliant Deposit (FCD) Date
2017-04-06Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC