Binge drinking differentially affects cortical and subcortical microstructure

Morris, Laurel S, Dowell, Nicholas G, Cercignani, Mara, Harrison, Neil A and Voon, Valerie (2017) Binge drinking differentially affects cortical and subcortical microstructure. Addiction Biology. ISSN 1355-6215

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Abstract

Young adult binge drinkers represent a model for endophenotypic risk factors for alcohol misuse and early exposure to repeated binge cycles. Chronic or harmful alcohol use leads to neurochemical, structural and morphological neuroplastic changes, particularly in regions associated with reward processing and motivation. We investigated neural microstructure in 28 binge drinkers compared with 38 matched healthy controls. We used a recently developed diffusion magnetic resonance imaging acquisition and analysis, which uses three-compartment modelling (of intracellular, extracellular and cerebrospinal fluid) to determine brain tissue microstructure features including neurite density and orientation dispersion index (ODI). Binge drinkers had reduced ODI, a proxy of neurite complexity, in frontal cortical grey matter and increased ODI in parietal grey matter. Neurite density was higher in cortical white matter in adjacent regions of lower ODI in binge drinkers. Furthermore, binge drinkers had higher ventral striatal grey matter ODI that was positively correlated with binge score. Healthy volunteers showed no such relationships. We demonstrate disturbed dendritic complexity of higher-order prefrontal and parietal regions, along with higher dendritic complexity of a subcortical region known to mediate reward-related motivation. The findings illustrate novel microstructural abnormalities that may reflect an infnce of alcohol bingeing on critical neurodevelopmental processes in an at-risk young adult group.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
Depositing User: Nicholas Dowell
Date Deposited: 25 Jan 2017 15:49
Last Modified: 19 Jul 2017 21:22
URI: http://sro.sussex.ac.uk/id/eprint/66467

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