Cytomegalovirus as a driver of excess cardiovascular mortality in rheumatoid arthritis: a red herring or a smoking gun?

Pera, Alejandra, Broadley, Iain, Davies, Kevin A and Kern, Florian (2017) Cytomegalovirus as a driver of excess cardiovascular mortality in rheumatoid arthritis: a red herring or a smoking gun? Circulation Research, 120 (2). pp. 274-277. ISSN 0009-7330

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Abstract

Rheumatoid arthritis (RA) is the most common inflammatory arthritis worldwide. Apart from its well known manifestations involving the joints (e.g. deformity, swelling, synovial inflammation), there are widespread, extra-articular manifestations that also involve the cardiovascular (CV) system. The consequences of CV involvement are often serious; cerebrovascular disease, ischemic heart disease and CV disease (CVD)-associated death are up to 50% higher in the context of RA leading to a reduction of life-expectancy in these patients of 3-10 years compared with the general population. To date, no satisfactory explanation of this phenomenon has been found, or maybe, it has been overlooked?

Item Type: Article
Keywords: Cardiovascular Disease, Rheumatoid Arthritis, Cytomegalovirus, CD4 T-cells
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Depositing User: Sandy Gray
Date Deposited: 18 Jan 2017 10:09
Last Modified: 20 Sep 2017 15:56
URI: http://sro.sussex.ac.uk/id/eprint/66325

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