Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients

Maniruzzaman, M, Islam, M T, Scoutaris, N, Nair, A and Douroumis, Dennis (2017) Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Drug Development and Industrial Pharmacy. ISSN 0363-9045

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Abstract

The purpose of this study was to evaluate the performance of Neusilin® (NEU) a synthetic magnesium aluminometasilicate as inorganic drug carrier co-processed with the hydrophilic surfactants Labrasol and Labrafil to develop Tranilast (TLT) based solid dispersions using continuous melt extrusion (HME) processing. Twin – screw extrusion was optimized to develop various TLT/excipient/surfactant formulations followed by continuous capsule filling in the absence of any downstream equipment. Physicochemical characterisation showed the existence of TLT in partially crystalline state in the porous network of inorganic NEU for all extruded formulations. Furthermore, the in line NIR studies revealed a possible intermolecular H–bonding formation between the drug and carrier resulting in the increase of dissolution of TLT. The capsules containing TLT extruded solid dispersions showed enhanced dissolution rates and compared with the marketed Rizaben® product.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Mohammed Maniruzzaman
Date Deposited: 16 Jan 2017 16:29
Last Modified: 08 Mar 2017 06:20
URI: http://sro.sussex.ac.uk/id/eprint/66227

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