Proposing arterial stiffness as an alternative way of assessing risk in transient ischaemic attack (TIA) patients

Ali, Khalid and Rajkumar, Chakravarthi (2016) Proposing arterial stiffness as an alternative way of assessing risk in transient ischaemic attack (TIA) patients. British Journal of Diabetes and Vascular Disease, 16 (1). pp. 16-19. ISSN 1474-6514

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Background: The ABCD2 score is a clinical tool currently categorising transient ischaemic attack (TIA) patients as low or high risk. Arterial stiffness, a novel physiological parameter predicting future cardiovascular events, has not been explored in TIA populations.

Methods: The following arterial stiffness parameters were measured in TIA patients aged >40 years: carotid-femoral pulse wave velocity (C-F PWV), carotid-radial pulse wave velocity (C-R PWV) using Complior® and central and peripheral blood pressure (BP) using Arteriograph®. Nocturnal BP dipping profiles were measured using 24-h ambulatory blood pressure monitoring. TIA participants were age- and gender-matched with healthy subjects to compare arterial stiffness and BP profiles.

Results: Twenty-four TIA patients, 50% male, of mean±SD age 70±10.1 years were recruited to the study. Mean±SD C-F PWV was 11.5±3.18 m/s and C-R PWV was 10.8±1.26 m/s. Published normative data for healthy age- and gender-matched subjects are C-F PWV 10.9 m/s and C-R PWV 10.1 m/s. Our TIA patients had higher central (130 mmHg) than peripheral BP (128 mmHg) compared with healthy subjects in whom central BP is 10–15 mmHg lower than peripheral BP. Thirty-eight percent of TIA patients lacked nocturnal dipping compared with 19% of healthy subjects.

Conclusions: In our TIA cohort we found increased arterial stiffness measurements compared to healthy subjects.

Item Type: Article
Keywords: stroke, TIA, arterial stiffness, blood pressure, ambulatory, dippers
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Marie Shelton
Date Deposited: 13 Jan 2017 13:16
Last Modified: 13 Jan 2017 13:16
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