New peptides under the s(ORF)ace of the genome

Pueyo-Marques, Jose L, Magny, Emile G and Couso, Juan P (2015) New peptides under the s(ORF)ace of the genome. Trends in Biochemical Sciences, 41 (8). pp. 665-678. ISSN 0968-0004

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Abstract

Hundreds of previously unidentified functional small peptides could exist in most genomes, but these sequences have been generally overlooked. The discovery of genes encoding small peptides with important functions in different organisms, has ignited the interest in these sequences, and led to an increasing amount of effort towards their identification. Here, we review the advances, both, computational, and biochemical, that are leading the way in the discovery of putatively functional smORFs, as well as the functional studies that have been carried out as a consequence of these searches. The evidence suggests that smORFs form a substantial part of our genomes, and that their encoded peptides could have important functions in a variety of cellular functions

Item Type: Article
Keywords: smORFs, peptides, Ribosome Profiling, peptidomics, LncRNAs, uORFs
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine
R Medicine > R Medicine (General) > R852 Research. Experimentation
R Medicine > R Medicine (General) > R852 Research. Experimentation > R853.C55 Clinical trials
R Medicine > R Medicine (General) > R855 Medical technology
R Medicine > R Medicine (General) > R856 Biomedical engineering. Electronics. Instrumentation
Depositing User: Juliet Kneller
Date Deposited: 12 Jan 2017 16:20
Last Modified: 21 Sep 2017 10:37
URI: http://sro.sussex.ac.uk/id/eprint/66151

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