Interspersed distribution of selectivity to kinematic stimulus features in supragranular layers of mouse barrel cortex

Martini, Francisco J, Molano-Mazón, Manuel and Maravall, Miguel (2017) Interspersed distribution of selectivity to kinematic stimulus features in supragranular layers of mouse barrel cortex. Cerebral Cortex. ISSN 1047-3211

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Abstract

Neurons in the primary sensory regions of neocortex have heterogeneous response properties. The spatial arrangement of neurons with particular response properties is a key aspect of population representations and can shed light on how local circuits are wired. Here we investigated how neurons with sensitivity to different kinematic features of whisker stimuli are distributed across local circuits in supragranular layers of the barrel cortex. Using two-photon calcium population imaging in anesthetized mice, we found that nearby neurons represent diverse kinematic features, providing a rich population representation at the local scale. Neurons interspersed in space therefore responded differently to a common stimulus kinematic feature. Conversely, neurons with similar feature selectivity were located no closer to each other than predicted by a random distribution null hypothesis. This finding relied on defining a null hypothesis that was specific for testing the spatial distribution of tuning across neurons. We also measured how neurons sensitive to specific features were distributed relative to barrel boundaries, and found no systematic organization. Our results are compatible with randomly distributed selectivity to kinematic features, with no systematic ordering superimposed upon the whisker map.

Item Type: Article
Keywords: map, sensory coding, somatosensory, somatotopy, tactile, two photon, vibrissae, whiskers, calcium, heterogeneity, neocortex, imaging, mice
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Subjects: Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0361 Nervous system
Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0431 Senses
Depositing User: Miguel Maravall
Date Deposited: 09 Mar 2017 15:50
Last Modified: 09 Mar 2017 16:38
URI: http://sro.sussex.ac.uk/id/eprint/66101

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Project NameSussex Project NumberFunderFunder Ref
N/AN/ASpanish Ministry of Science and InnovationBFU2011-23049
Sensory sequence representation and discrimination in cortical circuitsG1975MRC-Medical Research CouncilMR/P006639/1
N/AN/AValencia Regional GovernmentACOMP2010/199