Shunt peaking in neural membranes

Heras, Francisco J H, Laughlin, Simon B and Niven, Jeremy E (2016) Shunt peaking in neural membranes. Interface, 13 (124). ISSN 1742-5662

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Abstract

Capacitance limits the bandwidth of engineered and biological electrical circuits because it determines the gain–bandwidth product (GBWP). With a fixed GBWP, bandwidth can only be improved by decreasing gain. In engineered circuits, an inductance reduces this limitation through shunt peaking but no equivalent mechanism has been reported for biological circuits. We show that in blowfly photoreceptors a voltage-dependent K+ conductance, the fast delayed rectifier (FDR), produces shunt peaking thereby increasing bandwidth without reducing gain. Furthermore, the FDR's time constant is close to the value that maximizes the photoreceptor GBWP while reducing distortion associated with the creation of a wide-band filter. Using a model of the honeybee drone photoreceptor, we also show that a voltage-dependent Na+ conductance can produce shunt peaking. We argue that shunt peaking may be widespread in graded neurons and dendrites.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Research Centres and Groups: Centre for Computational Neuroscience and Robotics
Subjects: Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0361 Nervous system
Depositing User: Jeremy Niven
Date Deposited: 06 Jan 2017 12:41
Last Modified: 09 Aug 2017 19:46
URI: http://sro.sussex.ac.uk/id/eprint/66053

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