Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis

ahmadizar, Fariba, Vijverberg, Susanne J H, Arets, Hubertus G M, de Boer, Anthonius, Lang, Jason E, Kattan, Meyer, Palmer, Colin N A, Mukhopadhyay, Somnath, Turner, Steve and Maitland-van der Zee, Anke H (2016) Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis. European Respiratory Journal, 48 (4). pp. 1063-1073. ISSN 0903-1936

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Abstract

To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex. A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Antiinflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed- or random-effects models. In a meta-analysis of 46070 asthmatic children and adolescents, obese children (body mass index ⩾95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03–1.34; I2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n=4973, OR 1.23, 95% CI 0.99–1.53; I2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant. In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RJ Pediatrics > RJ0047.3 Genetic aspects
Depositing User: Katie Isaac
Date Deposited: 05 Jan 2017 10:44
Last Modified: 14 Aug 2017 04:18
URI: http://sro.sussex.ac.uk/id/eprint/66036

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