Neuron2016.pdf (2.94 MB)
Crossover inhibition generates sustained visual responses in the inner retina
journal contribution
posted on 2023-06-09, 04:04 authored by Juliana M Rosa, Sabine Ruehle, Huayu Ding, Leon LagnadoLeon LagnadoIn daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate these sustained channels within the inner retina of zebrafish. In OFF bipolar cells, sustained transmission was found to depend on crossover inhibition from the ON pathway through GABAergic amacrine cells. In ON bipolar cells, the amplitude of low-frequency signals was regulated by glycinergic amacrine cells, while GABAergic inhibition regulated the gain of band-pass signals. We also provide the first functional description of a subset of sustained ON bipolar cells in which synaptic activity was suppressed by fluctuations at frequencies above ~0.2 Hz. These results map out the basic circuitry by which the inner retina generates sustained visual signals and describes a new function of crossover inhibition.
History
Publication status
- Published
File Version
- Published version
Journal
NeuronISSN
1097-4199Publisher
ElsevierExternal DOI
Issue
2Volume
90Page range
308-19Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-11-21First Open Access (FOA) Date
2017-11-21First Compliant Deposit (FCD) Date
2017-11-21Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC