Crossover inhibition generates sustained visual responses in the inner retina

Rosa, Juliana M, Ruehle, Sabine, Ding, Huayu and Lagnado, Leon (2016) Crossover inhibition generates sustained visual responses in the inner retina. Neuron, 90 (2). pp. 308-19. ISSN 1097-4199

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Abstract

In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate these sustained channels within the inner retina of zebrafish. In OFF bipolar cells, sustained transmission was found to depend on crossover inhibition from the ON pathway through GABAergic amacrine cells. In ON bipolar cells, the amplitude of low-frequency signals was regulated by glycinergic amacrine cells, while GABAergic inhibition regulated the gain of band-pass signals. We also provide the first functional description of a subset of sustained ON bipolar cells in which synaptic activity was suppressed by fluctuations at frequencies above ∼0.2 Hz. These results map out the basic circuitry by which the inner retina generates sustained visual signals and describes a new function of crossover inhibition.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Depositing User: Leon Lagnado
Date Deposited: 21 Nov 2017 15:11
Last Modified: 21 Nov 2017 15:11
URI: http://sro.sussex.ac.uk/id/eprint/65518

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