DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA

James, J, Castellano, D and Eyre-Walker, A (2016) DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA. Heredity, 2017 (118). pp. 88-95. ISSN 0018-067X

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Abstract

Selection is expected to be more efficient in species that are more diverse because both the efficiency of natural selection and DNA sequence diversity are expected to depend upon the effective population size. We explore this relationship across a data set of 751 mammal species for which we have mitochondrial polymorphism data. We introduce a method by which we can examine the relationship between our measure of the efficiency of natural selection, the nonsynonymous relative to the synonymous nucleotide site diversity (πN/πS), and synonymous nucleotide diversity (πS), avoiding the statistical non-independence between the two quantities. We show that these two variables are strongly negatively and linearly correlated on a log scale. The slope is such that as πS doubles, πN/πS is reduced by 34%. We show that the slope of this relationship differs between the two phylogenetic groups for which we have the most data, rodents and bats, and that it also differs between species with high and low body mass, and between those with high and low mass-specific metabolic rate.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Research Centres and Groups: Centre for Byzantine Cultural History
Subjects: Q Science > QH Natural history > QH0301 Biology > QH0359 Evolution
Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics
Depositing User: Adam Eyre-Walker
Date Deposited: 16 Nov 2016 14:31
Last Modified: 10 May 2017 11:47
URI: http://sro.sussex.ac.uk/id/eprint/65512

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