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Theoretical modeling of oral absorption of barbiturates

journal contribution
posted on 2023-06-09, 03:26 authored by Taravat Ghafourian, Mohammad Barzegar-Jalali
The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.

History

Publication status

  • Published

File Version

  • Published version

Journal

Farmaco

ISSN

0014-827X

Publisher

Elsevier

External DOI

Issue

7

Volume

57

Page range

565-567

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2017-11-28

First Compliant Deposit (FCD) Date

2017-11-28

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    University of Sussex (Publications)

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    Keywords

    allobarbital; amobarbital; aprobarbital; barbital; barbituric acid derivative; butethal; cyclobarbital; ethallobarbital; hexobarbital; idobarbital; mephebarbital; methylphenobarbital; pentobarbital; phenobarbital; secbutabarbital; secobarbital; talbutal; unclassified drug; barbituric acid derivativeconference paper; drug absorption; electric potential; parameter; quantitative structure activity relation; stomach absorption; theoretical model; absorption; article; biological model; human; intestine absorption; metabolism; mouth mucosaAbsorption; Barbiturates; Human; Intestinal Absorption; ModelsBiological; Mouth Mucosa; Quantitative Structure-Activity Relationship; Absorption; Humans; Intestinal Absorption; Quantitative Structure-Activity Relationship

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