The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

Nokhodchi, A, Nazemiyeh, H, Ghafourian, T, Hassan-Zadeh, D, Valizadeh, H and Bahary, L A S (2002) The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations. Farmaco, 57 (11). pp. 883-888. ISSN 0014-827X

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Abstract

The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1 w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel. © 2002 �ditions scientifiques et médicales Elsevier SAS. All rights reserved.

Item Type: Article
Keywords: carboxymethylcellulose; diclofenac; Glycyrrhiza extract; glycyrrhizic acid; oil; penetration enhancing agent; water, animal tissue; article; controlled study; drug absorption; drug concentration; drug efficacy; drug formulation; drug isolation; emulsion; gel; Glycyrrhiza; glycyrrhiza glabra; male; nonhuman; plant root; rat; skin absorption; skin permeability, Administration, Topical; Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dialysis; Diclofenac; Emulsions; Excipients; Gels; Glycyrrhizic Acid; Male; Rats; Skin Absorption; Spectrophotometry, Ultraviolet
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Taravat Ghafourian
Date Deposited: 29 Nov 2017 09:38
Last Modified: 29 Nov 2017 09:38
URI: http://sro.sussex.ac.uk/id/eprint/64163
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