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Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model: effect of solute structure
journal contribution
posted on 2023-06-09, 03:26 authored by A Jouyban, M A A Fakhree, Taravat Ghafourian, A A Saei, W E Acree Jr.Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem® software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24, 48, and 53 to 16, 33 and 38, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction capability of the model being ~13%.
History
Publication status
- Published
Journal
PharmazieISSN
0031-7144Publisher
Govi Verlag GMBHExternal DOI
Issue
2Volume
63Page range
113-121Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2017-11-30Usage metrics
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acetazolamide; acetylsalicylic acid; adenine; adenosine; alcohol; aminophenazone; ampicillin; atropine; benzamide; benzoic acid; bumetanide; butyl paraben; butylcaine; carbamazepine; chloramphenicol; cimetidine; clofazimine; cortisone; dapsone; diflunisal; equilin; estriol; estrone; fenbufen; glafenine; macrogol; propylene glycol; solvent; unindexed drug; waterarticle; computer program; drug solubility; Jouyban Acree model; mathematical model; prediction; soluteAlgorithms; ChemistryPharmaceutical; Computer Simulation; Data InterpretationStatistical; Ethanol; ModelsChemical; ModelsStatistical; Pharmaceutical Preparations; Polyethylene Glycols; Software; Solubility; Solvents; Water
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