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Superantigens: microbial agents that corrupt immunity

journal contribution
posted on 2023-06-09, 02:53 authored by Martin LlewelynMartin Llewelyn, Jon Cohen
Microbial superantigens are a family of protein exotoxins that share the ability to trigger excessive and aberrant activation of T cells. The best characterised are the staphylococcal enterotoxins and the streptococcal pyrogenic exotoxins that trigger the staphylococcal and streptococcal toxic shock syndromes. It is now apparent that superantigens have a wider role in the pathology of infectious diseases than has previously been appreciated. Staphylococcus aureus and Streptococcus pyogenes together produce 19 different superantigens. The range of microorganisms known to produce superantigens has expanded to include Gram negative bacteria, mycoplasma, and viruses. Research is beginning to shed light on the more subtle parts these molecules play in causing disease and to produce some real possibilities for specific treatment of superantigen-induced toxicity. We aim to highlight these new developments and review the science behind these fascinating molecules.

History

Publication status

  • Published

Journal

Lancet Infectious Diseases

ISSN

1473-3099

Publisher

Elsevier

Issue

3

Volume

2

Page range

156-162

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-09-14

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    University of Sussex (Publications)

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