Hypertension and inflammation in Alzheimer's disease: close partners in disease development and progression!

Nelson, Lucy, Gard, Paul and Tabet, Naji (2014) Hypertension and inflammation in Alzheimer's disease: close partners in disease development and progression! Journal of Alzheimer's Disease, 41 (2). pp. 331-343. ISSN 1387-2877

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Abstract

Alzheimer's disease (AD) is by far the most common sporadic neurodegenerative disorder. Clinically it is associated with cognitive and other neuropsychological impairments, and neuropathologically it is distinguished by presence of amyloid-β plaques and neurofibrillary tangles. Hypertension has been traditionally associated with the etiology of vascular dementia, however, vascular risk factors including hypertension are increasingly being implicated in AD. Likewise, the importance of neuroinflammation in AD pathogenesis is also widely recognized. Data from animal and non-AD human studies suggest a close reciprocal relationship between hypertension and inflammatory systems. Much less is known on the potential pathological interaction between hypertension and inflammation in AD and its subsequent effects on amyloid and tau misfolding, aggregation, and propagation, events recognized as critical for the development and progression of AD. This review summarizes what is known about the mechanistic interactions between hypertension and inflammatory mediators and assesses their potential synergistic/additive role in AD genesis. Increasing our understanding of the pathological interactions between the recognized risk factors for AD is a worthwhile endeavor in a condition which currently has limited treatment options but an increasing number of potential preventative measures.

Item Type: Article
Keywords: Alzheimer's disease, Amyloid, Cerebrovasculature, Dementia, Hypertension, Inflammation
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > R Medicine (General) > R852 Research. Experimentation
Depositing User: Linda Bennett
Date Deposited: 13 Sep 2016 10:35
Last Modified: 18 Jul 2017 15:49
URI: http://sro.sussex.ac.uk/id/eprint/63271
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