Clinical usefulness of dopamine transporter SPECT imaging with 123I-FP-CIT in patients with possible dementia with Lewy bodies: randomised study

Walker, Zuzana, Moreno, Emilio, Thomas, Alan, Inglis, Fraser, Tabet, Naji, Rainer, Michael, Pizzolato, Gilberto, Padovani, Alessandro and the DADE Investigator Group, et al. (2015) Clinical usefulness of dopamine transporter SPECT imaging with 123I-FP-CIT in patients with possible dementia with Lewy bodies: randomised study. British Journal of Psychiatry, 206 (2). pp. 145-152. ISSN 0007-1250

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Abstract

BACKGROUND:

Dementia with Lewy bodies (DLB) is underrecognised in clinical settings.

AIMS:

To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission computed tomography (SPECT) scan in patients with possible DLB would lead to a more certain diagnosis (probable DLB or non-DLB dementia).

METHOD:

We randomised 187 patients with possible DLB 2:1 to have a scan or not (control group). The outcome measure was a change in diagnosis to probable DLB or non-DLB.

RESULTS:

There were 56 controls and 114 scanned patients, of whom 43% had an abnormal scan. More patients in the imaging group had a change in diagnosis compared with controls at 8 and 24 weeks (61% (n = 70) v. 4% (n = 2) and 71% (n = 77) v. 16% (n = 9); both P<0.0001). Clinicians were more likely to change the diagnosis if the scan was abnormal (82%) than if it was normal (46%).

CONCLUSIONS:

Imaging significantly contributed to a more certain diagnosis, proving to be a useful adjunct in the work-up of patients with possible DLB.

Royal College of Psychiatrists.

Item Type: Article
Keywords: Dopamine, SPECT imagine 1231-FP-CIT, Randomised study
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > R Medicine (General) > R852 Research. Experimentation
R Medicine > R Medicine (General) > R852 Research. Experimentation > R853.C55 Clinical trials
Depositing User: Linda Bennett
Date Deposited: 13 Sep 2016 10:09
Last Modified: 18 Jul 2017 16:04
URI: http://sro.sussex.ac.uk/id/eprint/63269
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