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The roles of the exoribonucleases DIS3L2 and XRN1 in disease

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posted on 2023-06-09, 02:43 authored by Amy L Pashler, Benjamin TowlerBenjamin Towler, Chris JonesChris Jones, Sarah NewburySarah Newbury
RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is known about their specific roles in development of multicellular organisms or human disease. This review focusses on the roles of DIS3L2 and XRN1 in the pathogenesis of human disease, particularly in relation to phenotypes seen in model organisms. The known diseases associated with loss of activity of DIS3L2 and XRN1 are discussed, together with possible mechanisms and cellular pathways leading to these disease conditions.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Biochemical Society Transactions

ISSN

0300-5127

Publisher

Portland Press

Issue

5

Volume

44

Page range

1377-1384

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-09-05

First Open Access (FOA) Date

2017-10-20

First Compliant Deposit (FCD) Date

2016-09-07

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