Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention

Wendler, F, Favicchio, R, Simon, T, Alifrangis, C, Stebbing, J and Giamas, G (2017) Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention. Oncogene, 36 (7). pp. 877-884. ISSN 0950-9232

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Abstract

Intercellular communication sets the pace for transformed cells to survive and to thrive. Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this process shuttling reciprocal signals and other molecules between transformed and stromal cells, including fibroblasts, endothelial and immune cells. As a result, these cells are adapted or recruited to a constantly evolving cancer microenvironment. Moreover, EVs take part in the response to anticancer therapeutics not least by promoting drug resistance throughout the targeted tumor. Finally, circulating EVs can also transport important molecules to remote destinations in order to prime metastatic niches in an otherwise healthy tissue. Although the understanding of EV biology remains a major challenge in the field, their characteristics create new opportunities for advances in cancer diagnostics and therapeutics.

Item Type: Article
Keywords: Extracellular vesicles, Exosomes, Tumor–stroma communication, Cancer microenvironment
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > Q Science (General)
Related URLs:
Depositing User: Georgios Giamas
Date Deposited: 26 Aug 2016 14:35
Last Modified: 06 Mar 2017 21:21
URI: http://sro.sussex.ac.uk/id/eprint/63032

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