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Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment

journal contribution
posted on 2023-06-09, 02:33 authored by Feng Bai, Zhijun Zhanga, David R Watson, Hui Yu, Yongmei Shi, Wanlin Zhud, Liang Wang, Yonggui Yuan, Yun Qian
Hippocampus displayed progressively gender-associated damage in Alzheimer’s disease. However, gender effects have been largely neglected in studies of amnestic type mild cognitive impairment (aMCI)patients who were believed to represent an early stage of this disease. The goal of this study was to use in vivo neuroimaging techniques to determine whether there were any evidences of gender differences in hippocampal atrophy in aMCI. A region of interest-based magnetic resonance imaging approach was used to compare hippocampal volume between aMCI patients (22 male, 17 female) and normal aging controls (12 male, 11 female). Independent of group, male hippocampal volumes were larger than female volumes and right hippocampal volumeswere typically smaller than left volumes. Hippocampal volumes were significantly reduced in the clinical group but no gender differenceswere noted in terms of degree of atrophy present. However, female patients showed more impaired cognitive function than male patients despite this apparent equivalence in atrophy. The absence of a gender difference suggested that early neuropathological progression might be independent of gender. However, the data also suggested female aMCI patients had an increased vulnerability to cognitive impairment earlier in the illness course.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neuroscience Letters

ISSN

0304-3940

Publisher

Elsevier

Issue

2

Volume

450

Page range

85-89

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-16

First Compliant Deposit (FCD) Date

2016-08-16

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