Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment

Bai, Feng, Zhang, Zhijun, Watson, David R, Yu, Hui, Shi, Yongmei, Yuan, Yonggui, Qian, Yun and Jia, Jianping (2009) Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment. Journal of the Neurological Sciences, 278 (1-2). pp. 102-106. ISSN 0022-510X

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Abstract

The association fiber tracts integrity of the inter-hemispheric and within-hemispheric communication was
poor understood in amnestic type mild cognitive impairment (aMCI) patients by diffusion tensor imaging
(DTI). A region of interest-based DTI approach was applied to explore fiber tract differences between 22 aMCI patients and 22 well-matched normal aging. Correlations were also sought between fractional anisotropy (FA) values and the cognitive performance scores in the aMCI patients. Extensive impairment of association fiber tracts integrity was observed in aMCI patients, including bilateral inferior fronto-occipital fascicles, the genu of corpus callosum, bilateral cingulate bundles and bilateral superior longitudinal fascicles II (SLE II) subcomponent. In addition, the FA value of right SLE II was significantly negatively correlated to the performance of Trail Making Test A and B, whilst the values of right posterior cingulate bundle was significantly positive correlation with MMSE score. As aMCI is a putative prodromal syndrome to Alzheimer's
disease (AD), this study suggested that investigation of association fiber tracts between remote cortexes may
yield important new data to predict whether a patient will eventually develop AD.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Parisa Rafizadeh-Farahani
Date Deposited: 10 Aug 2016 14:51
Last Modified: 07 Mar 2017 06:52
URI: http://sro.sussex.ac.uk/id/eprint/62357

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