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Rapid protium-deuterium exchange of 4-aminopyridines in neutral D2O under microwave irradiation

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posted on 2023-06-09, 02:17 authored by Mark BagleyMark Bagley, Ayed Alnomsy, Hussein I Sharhan
4-Aminopyridines undergo surprisingly rapid and highly-selective H/D exchange at C-2 and C-6 in neutral D2O upon microwave irradiation at only 190 °C for 2 h in a sealed vessel. This method contrasts and complements acid-mediated H/D exchange, requires no catalyst and is appropriate for the synthesis of deuterium isotop-ologues of N- and C-substituted 4-aminopyridines and a ben-zofused (quinoline) analogue.

Funding

PhD Studentship; registration 21216348; Saudi Cultural Bureau; i532

Alignment of Synthesis, Medicinal Chemistry and Structural Genomics to Accelerate (Strathclyde lead); G0926; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; RKES 115428

PhD Studentship; registration 21319586; Iraqi Cultural Attache; S 694

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Synlett

ISSN

0936-5214

Publisher

Georg Thieme Verlag

Issue

17

Volume

27

Page range

2467-2472

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-15

First Open Access (FOA) Date

2017-08-04

First Compliant Deposit (FCD) Date

2016-08-15

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