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Rapid protium-deuterium exchange of 4-aminopyridines in neutral D2O under microwave irradiation
journal contribution
posted on 2023-06-09, 02:17 authored by Mark BagleyMark Bagley, Ayed Alnomsy, Hussein I Sharhan4-Aminopyridines undergo surprisingly rapid and highly-selective H/D exchange at C-2 and C-6 in neutral D2O upon microwave irradiation at only 190 °C for 2 h in a sealed vessel. This method contrasts and complements acid-mediated H/D exchange, requires no catalyst and is appropriate for the synthesis of deuterium isotop-ologues of N- and C-substituted 4-aminopyridines and a ben-zofused (quinoline) analogue.
Funding
PhD Studentship; registration 21216348; Saudi Cultural Bureau; i532
Alignment of Synthesis, Medicinal Chemistry and Structural Genomics to Accelerate (Strathclyde lead); G0926; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; RKES 115428
PhD Studentship; registration 21319586; Iraqi Cultural Attache; S 694
History
Publication status
- Published
File Version
- Accepted version
Journal
SynlettISSN
0936-5214Publisher
Georg Thieme VerlagExternal DOI
Issue
17Volume
27Page range
2467-2472Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-08-15First Open Access (FOA) Date
2017-08-04First Compliant Deposit (FCD) Date
2016-08-15Usage metrics
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