Rapid protium-deuterium exchange of 4-aminopyridines in neutral D2O under microwave irradiation

Bagley, Mark C, Alnomsy, Ayed and Sharhan, Hussein I (2016) Rapid protium-deuterium exchange of 4-aminopyridines in neutral D2O under microwave irradiation. Synlett. ISSN 0936-5214

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Abstract

4-Aminopyridines undergo surprisingly rapid and highly-selective H/D exchange at C-2 and C-6 in neutral D2O upon microwave irradiation at only 190 °C for 2 h in a sealed vessel. This method contrasts and complements acid-mediated H/D exchange, requires no catalyst and is appropriate for the synthesis of deuterium isotop-ologues of N- and C-substituted 4-aminopyridines and a ben-zofused (quinoline) analogue.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User: Mark Bagley
Date Deposited: 15 Aug 2016 10:14
Last Modified: 04 Aug 2017 12:16
URI: http://sro.sussex.ac.uk/id/eprint/62146

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