Conservation of upstream regulators of scute on the notum of cyclorraphous Diptera

Simpson, Pat, Lewis, Morag and Richardson, Joanna (2006) Conservation of upstream regulators of scute on the notum of cyclorraphous Diptera. Development Genes and Evolution, 216 (7). pp. 363-371. ISSN 0949-944X

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Abstract

Bristles on the notum of many cyclorraphous flies are arranged into species-specific stereotyped patterns. Differences in the spatial expression of the proneural gene scute correlate with the positions of bristles in those species looked at so far. However, the examination of a number of genes encoding trans-regulatory factors, such as pannier, stripe, u-shaped, caupolican and wingless, indicates that they are expressed in conserved domains on the prospective notum. This suggests that the function of a trans-regulatory network of genes is relatively unchanged in derived Diptera, and that many differences are likely to be due to changes in cis-regulatory sequences of scute. In contrast, in Anopheles gambiae, a basal species with no stereotyped bristle pattern, the expression patterns of pannier and wingless are not conserved, and expression of AgASH, the Anopheles proneural gene, does not correlate in a similar manner with the bristle pattern. We discuss the possibility that independently acting cis-regulatory sequences at the scute locus may have arisen in the lineage giving rise to cyclorraphous flies.

Item Type: Article
Keywords: Calliphora, Bristle pattern, Scute, Cyclorraphous flies
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QL Zoology > QL0951 Embryology
Depositing User: Joanna Richardson
Date Deposited: 27 Jul 2016 15:39
Last Modified: 08 Mar 2017 04:57
URI: http://sro.sussex.ac.uk/id/eprint/62127

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