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Separate and combined effects of genetic variants and pre-treatment whole blood gene expression on response to exposure-based cognitive behavioural therapy for anxiety disorders

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posted on 2023-06-09, 02:10 authored by Jonathan R I Coleman, Kathryn LesterKathryn Lester, Susanna Roberts, Robert Keers, Sang hyuck Lee, Simone De Jong, Héléna Gaspar, Tobias Teismann, André Wannemüller, Silvia Schneider, Peter Jöhren, Jürgen Margraf, Gerome Breen, Thalia C Eley
Objectives: Exposure-based cognitive behavioural therapy (eCBT) is an effective treatment for anxiety disorders. Response varies between individuals. Gene expression integrates genetic and environmental influences. We analysed the effect of gene expression and genetic markers separately and together on treatment response. Methods: Adult participants (n?=?181) diagnosed with panic disorder or a specific phobia underwent eCBT as part of standard care. Percentage decrease in the Clinical Global Impression severity rating was assessed across treatment, and between baseline and a 6-month follow-up. Associations with treatment response were assessed using expression data from 3,233 probes, and expression profiles clustered in a data- and literature-driven manner. A total of 3,343,497 genetic variants were used to predict treatment response alone and combined in polygenic risk scores. Genotype and expression data were combined in expression quantitative trait loci (eQTL) analyses. Results: Expression levels were not associated with either treatment phenotype in any analysis. A total of 1,492 eQTLs were identified with q?

History

Publication status

  • Published

File Version

  • Accepted version

Journal

World Journal of Biological Psychiatry

ISSN

1562-2975

Publisher

Taylor & Francis

Issue

3

Volume

18

Page range

215-226

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-07-15

First Open Access (FOA) Date

2017-08-25

First Compliant Deposit (FCD) Date

2016-07-15

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