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Heterogeneity of phenotype and function reflects the multistage development of T follicular helper cells

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posted on 2023-06-09, 01:55 authored by Marta Trub, Tom A. Barr, Vicky L Morrison, Sheila Brown, Stefano Caserta, Jordan Rixon, Alasdair Ivens, David Gray
T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1hi Tfh are important in the GC response, the function of the PD1lo Tfh-like subset is unknown. We show that these cells, like the PD1hi GC–Tfh, depend upon B cells; however, their entry to follicles is independent of CXCR5 or cognate interactions with B cells. The differentiation into PD1hi Tfh is dependent on MHC class II interactions with B cells and requires CXCR5. Our data suggest a Tfh differentiation pathway that is initially B cell-independent, then dependent on non-cognate B cell interactions, and finally following cognate interaction with B cells and CXCR5-ligands allows the formation of GC–Tfh. The PD1lo Tfh-like cells make early cytokine responses and may represent precursors of CD4 memory cells.

History

Publication status

  • Published

File Version

  • Published version

Journal

Frontiers in Immunology

ISSN

1664-3224

Publisher

Frontiers Media

Volume

8

Article number

a489

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-04-28

First Open Access (FOA) Date

2017-04-28

First Compliant Deposit (FCD) Date

2017-04-28

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