Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment

Bai, Feng, Watson, David R, Hui, Yu, Yongmei, Shi, Yonggui, Yuan and Zhijun, Zhang (2009) Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment. Brain Research, 1302. pp. 167-174. ISSN 0006-8993

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Abstract

Amnestic type mild cognitive impairment (aMCI) refers to a transitional stage between
normal aging and Alzheimer's disease (AD). Whilst posterior cingulate cortex (PCC) is
believed to have a key role in a default network and be involved in the pathophysiology of
AD, few studies have investigated whole-brain functional connectivity of PCC during resting
state, or investigated the relationship between abnormal functional connectivity and
disturbance in cognitive function in aMCI patients. Resting-state functional connectivity
analysis was used to examine the temporal correlation between PCC and whole-brain
regions in 30 aMCI patients and 26 well-matched controls. Further analysis involved
evaluation of possible relationships between functional connectivity measures and
cognitive function. Regions of decreased functional connectivity were identified in aMCI
patients, most notably in temporal cortex, whilst significantly increased functional
connectivity was mainly in frontal cortex. In addition, functional connectivity of PCC and
temporal cortex was associated with the performance of neuropsychological tests in aMCI
patients. This would be consonant with the recruitment of compensatory mechanisms and
the process of offset functional impairments appearing as neuropathologic develops, and
resting-state connectivity disturbance of PCC–temporal cortex may be a central role in
cognitive deficit in aMCI patients.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Related URLs:
Depositing User: Parisa Rafizadeh-Farahani
Date Deposited: 03 Aug 2016 13:17
Last Modified: 22 Mar 2017 03:33
URI: http://sro.sussex.ac.uk/id/eprint/61727

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