Regioselective routes to orthogonally-substituted aromatic MIDA boronates.pdf (822 kB)
Regioselective routes to orthogonally-substituted aromatic MIDA boronates
Version 2 2023-06-12, 06:40
Version 1 2023-06-09, 01:45
journal contribution
posted on 2023-06-12, 06:40 authored by Adam J Close, Paul Kemmitt, S Mark Roe, John SpencerJohn SpencerA series of tetrasubstituted aromatics has been synthesized, many of which are based on elaborated N-methyliminodiacetic acid (MIDA)-boronates. A sequence employing nitration, bromination, stepwise Suzuki-Miyaura (SM) coupling with a boronic acid, then base-mediated unmasking of the boronic acid from the MIDA-boronate and a second SM-coupling has led to our desired, mainly 1,2,4,5-substituted tetrasubstituted aromatic targets.
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- Published
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- Published version
Journal
Organic and Biomolecular ChemistryISSN
1477-0520Publisher
Royal Society of ChemistryExternal DOI
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28Volume
14Page range
6751-6756Department affiliated with
- Chemistry Publications
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- Yes
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- Yes
Legacy Posted Date
2016-06-20First Open Access (FOA) Date
2017-01-23First Compliant Deposit (FCD) Date
2016-06-18Usage metrics
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