Regioselective routes to orthogonally-substituted aromatic MIDA boronates

Close, Adam J, Kemmitt, Paul, Roe, S Mark and Spencer, John (2016) Regioselective routes to orthogonally-substituted aromatic MIDA boronates. Organic and Biomolecular Chemistry, 14 (28). pp. 6751-6756. ISSN 1477-0520

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Abstract

A series of tetrasubstituted aromatics has been synthesized, many of which are based on elaborated N-methyliminodiacetic acid (MIDA)-boronates. A sequence employing nitration, bromination, stepwise Suzuki-Miyaura (SM) coupling with a boronic acid, then base-mediated unmasking of the boronic acid from the MIDA-boronate and a second SM-coupling has led to our desired, mainly 1,2,4,5-substituted tetrasubstituted aromatic targets.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User: John Spencer
Date Deposited: 20 Jun 2016 08:55
Last Modified: 12 Sep 2017 15:42
URI: http://sro.sussex.ac.uk/id/eprint/61589

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