Phosphine-free chiral iridium catalysts for asymmetric catalytic hydrogenation of simple ketones

Kumar, Prashant, Irrgang, Torsten, Kostakis, George E and Kempe, Rhett (2016) Phosphine-free chiral iridium catalysts for asymmetric catalytic hydrogenation of simple ketones. RSC Advances, 6 (45). pp. 39335-39342. ISSN 2046-2069

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Abstract

Novel pyridylalkylamine and aminopyridinato ligand stabilized iridium complexes with no P ligand are introduced. These complexes have been investigated as catalysts for asymmetric hydrogenation of simple ketones, resulting in an active catalyst for bulky alkyl aryl ketones that is α-methylpropiophenone. The ligands were synthesized from inexpensive starting materials and their modular design allows for the introduction of a broad variety of substitution patterns. Additionally, better activity and selectivity was observed at 20 °C and 20 bar H2 pressure with a catalyst loading as low as 0.05 mol% iridium. These phosphorus free catalysts have always been a central issue in both academic and industrial research.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0146 Inorganic chemistry
Depositing User: Georgios Kostakis
Date Deposited: 15 Jun 2016 10:40
Last Modified: 22 Aug 2017 16:22
URI: http://sro.sussex.ac.uk/id/eprint/61503

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