Electric potential sensors: novel biosensors for cardio-electrophysiology in embryos

Rendon-Morales, E, Prance, R J, Prance, H and Aviles-Espinosa, R (2016) Electric potential sensors: novel biosensors for cardio-electrophysiology in embryos. In: Sensors 2016 Wearable Smart Sensors and Technologies, Tuesday, 21st June 2016, London- Royal Society of Chemistry. (Accepted)

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Abstract

Currently, there is no effective sensing technology available to monitor the electrocardiogram(ECG) activity of the living zebrafish heart during early developmental stages. Most of the methods are based either on the use of simple visual inspections which are limited to quantifying the heart-rate or invasive methodologies which require the insertion of electrodes or heart explantation techniques, both requiring the use of expensive differential amplifiers and noise isolated environments.
In this paper we report the continuous detection of the cardiac electrical activity in embryonic zebrafish using a non-invasive approach. We present a portable and cost-effective platform based on the Sussex patented Electric Potential Sensing(EPS) technology, to monitor in vivo electrocardiogram activity from the zebrafish heart. We present results using the experimental prototype, which enables the acquisition of cardio-electrophysiological signals from in vivo 3, 4 and 5 days-post-fertilization(dpf) zebrafish embryos.

Item Type: Conference or Workshop Item (Paper)
Keywords: Biosensors, Biotechnology, Cardiology, embryonic development, zebrafish
Schools and Departments: School of Engineering and Informatics > Informatics
Subjects: T Technology > TA Engineering (General). Civil engineering (General) > TA0164 Bioengineering
T Technology > TA Engineering (General). Civil engineering (General) > TA0165 Engineering instruments, meters, etc. Industrial instrumentation
T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK0301 Electric meters
T Technology > TP Chemical technology > TP0248.13 Biotechnology
Depositing User: Elizabeth Rendon Morales
Date Deposited: 14 Jun 2016 06:50
Last Modified: 14 Jun 2016 06:50
URI: http://sro.sussex.ac.uk/id/eprint/61458

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