The effects of L-AP4 and L-serine-O-phosphate on inhibition in primary somatosensory cortex of the adult rat in vivo

Wan, H and Cahusac, P M B (1995) The effects of L-AP4 and L-serine-O-phosphate on inhibition in primary somatosensory cortex of the adult rat in vivo. Neuropharmacology, 34 (8). pp. 1053-1062. ISSN 0028-3908

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Abstract

The effects of two iontophoretically applied Group III mGluR agonists were studied on the inhibition in neocortex produced by natural stimulation of vibrissae. The agonists L-AP4 and L-serine-O-phosphate (L-SOP) were shown to produce qualitatively similar effects on the inhibition. Forty-four percent of neurones (total n = 57) displayed disinhibition during application of the agonists. The disinhibitory effects often outlasted the offset of the agonist application by at least 10 min. Concurrent application of the mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine ((+)-MCPG) appeared to reverse the disinhibitory effects of L-AP4 and L-SOP in 3 out of 5 neurones tested. However (+)-MCPG itself was found to have disinhibitory effects in some neurones. Some neurones (n = 7) showed increases in inhibition during either L-AP4 or L-SOP application. These appeared most pronounced in those neurones where the initial (pre-drug) inhibition was minimal, perhaps suggesting that the agonists were disinhibiting a local disinhibition. The data obtained in the experiments suggest that the disinhibitory effects are mediated by a heteroreceptor on inhibitory terminals, action at which depresses the release of inhibitory transmitter. The possible role of the modulation of inhibition by presynaptic mGluRs is discussed.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Depositing User: Huimin Wan
Date Deposited: 07 Apr 2017 09:23
Last Modified: 07 Apr 2017 09:28
URI: http://sro.sussex.ac.uk/id/eprint/61418

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