Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues

McGuigan, Christopher, Serpi, Michaela, Slusarczyk, Magdalena, Ferrari, Valentina, Pertusati, Fabrizio, Meneghesso, Silvia, Derudas, Marco, Farleigh, Laura, Zanetta, Paola and Bugert, Joachim (2016) Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues. ChemistryOpen, 2016 (5). pp. 227-235. ISSN 2191-1363

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Abstract

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Marco Derudas
Date Deposited: 09 Sep 2016 06:39
Last Modified: 06 Mar 2017 16:06
URI: http://sro.sussex.ac.uk/id/eprint/61411

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