Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer

Angelopoulos, Nicos, Stebbing, Justin, Xu, Yichen, Giamas, Georgios and Zhang, Hua (2016) Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer. Data in Brief, 7. pp. 740-746. ISSN 2352-3409

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Abstract

Tyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics, a global functional proteomic landscape of TKs in breast cancer was recently revealed highlighting a comprehensive and highly integrated signaling network regulated by TKs (Stebbing et al., 2015) [1]. We collate the enormous amount of the proteomic data in an open access platform, providing a valuable resource for studying the function of TKs in cancer and benefiting the science community. Here we present a detailed description related to this study (Stebbing et al., 2015) [1] and the raw data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the identifier PXD002065.

Item Type: Article
Keywords: Breast cancer, Cell signaling, Proteomics, SILAC, Tyrosine kinases
Schools and Departments: School of Life Sciences > Biochemistry
Related URLs:
Depositing User: Georgios Giamas
Date Deposited: 18 May 2016 09:30
Last Modified: 06 Mar 2017 19:57
URI: http://sro.sussex.ac.uk/id/eprint/61059

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