Alzheimer's disease

University of Sussex (2016) Alzheimer's disease. .

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Abstract

The invention relates to Alzheimer's disease (AD), and particularly, although not exclusively, to Amyloid-beta (Αβ or Abeta), and variants thereof. The invention also includes kits comprising a variant Αβ, and to uses of these kits and Αβ variants in Αβ studies, for example in assays and methods for screening novel compounds for use in treating AD.

Alzheimer's disease (AD) is characterized by the deposition of Αβ in extracellular amyloid plaques, as well as the intracellular accumulation of tau in neurofibrillary tangles in the brain. Mutations in Αβ and the Amyloid precursor protein (APP) are linked to familial AD, and therefore Αβ is thought to play an important role in the disease process. Numerous studies have been conducted to try to better understand how Αβ is involved in the neurodegeneration observed in AD patients and the symptoms of the disease. Some of these studies have been conducted in transgenic animals whilst others have used biomimetic membranes, cultured neurons or animal injection to investigate the direct effect of oligomeric and fibrillar Αβ in these systems.

Item Type: Patent
Keywords: Abeta, Alzheimer's, Amyloid
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Louise Serpell
Date Deposited: 25 Apr 2016 10:09
Last Modified: 26 Apr 2016 11:54
URI: http://sro.sussex.ac.uk/id/eprint/60602

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Project NameSussex Project NumberFunderFunder Ref
BBSRC SPARKING IMPACT AWARDG1194BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL4020007700