Discovery and characterization of smORF-encoded bioactive polypeptides

Saghatelian, Alan and Couso, Juan Pablo (2015) Discovery and characterization of smORF-encoded bioactive polypeptides. Nature Chemical Biology, 11 (12). pp. 909-916. ISSN 1552-4469

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Abstract

Analysis of genomes, transcriptomes and proteomes reveals the existence of hundreds to thousands of translated, yet non-annotated, short open reading frames (small ORFs or smORFs). The discovery of smORFs and their protein products, smORF-encoded polypeptides (SEPs), points to a fundamental gap in our knowledge of protein-coding genes. Various studies have identified central roles for smORFs in metabolism, apoptosis and development. The discovery of these bioactive SEPs emphasizes the functional potential of this unexplored class of biomolecules. Here, we provide an overview of this emerging field and highlight the opportunities for chemical biology to answer fundamental questions about these novel genes. Such studies will provide new insights into the protein-coding potential of genomes and identify functional genes with roles in biology and disease.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine
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Depositing User: Patricia Butler
Date Deposited: 22 Apr 2016 15:57
Last Modified: 22 Apr 2016 15:57
URI: http://sro.sussex.ac.uk/id/eprint/60597
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