Different patterns of correlation between grey and white matter integrity account for behavioral and psychological symptoms in Alzheimer's disease

Makovac, Elena, Serra, Laura, Spanò, Barbara, Giulietti, Giovanni, Torso, Mario, Cercignani, Mara, Caltagirone, Carlo and Bozzali, Marco (2016) Different patterns of correlation between grey and white matter integrity account for behavioral and psychological symptoms in Alzheimer's disease. Journal of Alzheimer's Disease, 50 (2). pp. 591-604. ISSN 1387-2877

Full text not available from this repository.

Abstract

Behavioral disorders and psychological symptoms (BPSD) in Alzheimer's disease (AD) are known to correlate with grey matter (GM) atrophy and, as shown recently, also with white matter (WM) damage. WM damage and its relationship with GM atrophy are reported in AD, reinforcing the interpretation of the AD pathology in light of a disconnection syndrome. It remains uncertain whether this disconnection might account also for different BPSD observable in AD. Here, we tested the hypothesis of different patterns of association between WM damage of the corpus callosum (CC) and GM atrophy in AD patients exhibiting one of the following BPSD clusters: Mood (i.e., anxiety and depression; ADmood), Frontal (i.e., dishinibition and elation; ADfrontal), and Psychotic (delusions and hallucinations; ADpsychotic) related symptoms, as well as AD patients without BPSD. Overall, this study brings to light the strict relationship between WM alterations in different parts of the CC and GM atrophy in AD patients exhibiting BPSD, supporting the hypothesis that such symptoms are likely to be caused by characteristic patterns of neurodegeneration of WM and GM, rather than being a reactive response to accumulation of cognitive disabilities, and should therefore be regarded as potential markers of diagnostic and prognostic value in AD.

Item Type: Article
Keywords: Alzheimer’s disease, Behavioural, Grey matter, Magnetic resonance imaging, White matter
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Depositing User: Patricia Butler
Date Deposited: 14 Jul 2016 14:59
Last Modified: 25 Jul 2017 10:52
URI: http://sro.sussex.ac.uk/id/eprint/60365
📧 Request an update